Honeybee venom induces calcium-dependent but caspase-independent apoptotic cell death in human melanoma A2058 cells
WC Tu, CC Wu, HL Hsieh, CY Chen, SL Hsu - Toxicon, 2008 - Elsevier
Honeybee (Apis mellifera) venom (BV) has been reported to exhibit anticancer effects, but its
mode of action at the cellular and molecular levels remains largely unknown. We found that
honeybee venom induced apoptosis in human melanoma A2058 cells but not in normal skin
fibroblast Detroit 551 cells. The BV-induced apoptosis was accompanied by generation of
reactive oxygen species and alteration of mitochondrial membrane potential transition.
Treatment with antioxidants significantly attenuated BV-induced apoptosis. Although …
mode of action at the cellular and molecular levels remains largely unknown. We found that
honeybee venom induced apoptosis in human melanoma A2058 cells but not in normal skin
fibroblast Detroit 551 cells. The BV-induced apoptosis was accompanied by generation of
reactive oxygen species and alteration of mitochondrial membrane potential transition.
Treatment with antioxidants significantly attenuated BV-induced apoptosis. Although …