[HTML][HTML] Platelets express three different splice variants of ApoER2 that are all involved in signaling
MTT Pennings, R Derksen, RT Urbanus… - Journal of Thrombosis …, 2007 - Elsevier
Background: β2‐Glycoprotein I is the most relevant antigen in antiphospholipid syndrome.
We have shown that binding of dimerized β2‐GPI to platelets via ApoER2′ sensitizes
platelets for second activating stimuli. Objective: Determine the region of ApoER2 involved
in the binding of dimeric β2‐GPI. Methods: Cultured human megakaryocytes (MK) and three
different human megakaryocytic cell lines were used for mRNA isolation to clone and
express recombinant soluble platelet ApoER2. Domain deletion mutants of ApoER2 were …
We have shown that binding of dimerized β2‐GPI to platelets via ApoER2′ sensitizes
platelets for second activating stimuli. Objective: Determine the region of ApoER2 involved
in the binding of dimeric β2‐GPI. Methods: Cultured human megakaryocytes (MK) and three
different human megakaryocytic cell lines were used for mRNA isolation to clone and
express recombinant soluble platelet ApoER2. Domain deletion mutants of ApoER2 were …
