[HTML][HTML] Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity
GL Guo, G Lambert, M Negishi, JM Ward… - Journal of Biological …, 2003 - ASBMB
The nuclear receptors, farnesoid X receptor (FXR) and pregnane X receptor (PXR), are
important in maintaining bile acid homeostasis. Deletion of both FXR and PXR in vivo by
cross-breeding B6; 129-Fxr tm1Gonz (FXR-null) and B6; 129-Pxr tm1Glaxo-Wellcome (PXR-
null) mice revealed a more severe disruption of bile acid, cholesterol, and lipid homeostasis
in B6; 129-Fxr tm1Gonz Pxr tm1Glaxo-Wellcome (FXR-PXR double null or FPXR-null) mice
fed a 1% cholic acid (CA) diet. Hepatic expression of the constitutive androstane receptor …
important in maintaining bile acid homeostasis. Deletion of both FXR and PXR in vivo by
cross-breeding B6; 129-Fxr tm1Gonz (FXR-null) and B6; 129-Pxr tm1Glaxo-Wellcome (PXR-
null) mice revealed a more severe disruption of bile acid, cholesterol, and lipid homeostasis
in B6; 129-Fxr tm1Gonz Pxr tm1Glaxo-Wellcome (FXR-PXR double null or FPXR-null) mice
fed a 1% cholic acid (CA) diet. Hepatic expression of the constitutive androstane receptor …
