Contribution of host radioresistant T cells to the clonal elimination of minor lymphocyte stimulatory-1a reactive T cells in mouse bone marrow chimeras
N Arase, H Arase, RA Good, K Onoé - Cellular immunology, 1994 - Elsevier
When bone marrow (BM) cells from IE+ and minor lymphocyte stimulatory (Mls) antigen (Ag)
disparate mice (Mls-1 b) were transplanted to lethally irradiated Mls-1 a reactive, Mls-1 a
reactive T cells were found to be completely deleted from the developing thymocyte
population in these [Mls-1 b→ Mls-1 a] radiation chimeras. It has been shown that BM-
derived class II (Ia) positive cells play an essential role in this clonal deletion. Thus, Mls-1 a
Ag appeared to have been transferred from recipient cells to the Ia+ cells derived from donor …
disparate mice (Mls-1 b) were transplanted to lethally irradiated Mls-1 a reactive, Mls-1 a
reactive T cells were found to be completely deleted from the developing thymocyte
population in these [Mls-1 b→ Mls-1 a] radiation chimeras. It has been shown that BM-
derived class II (Ia) positive cells play an essential role in this clonal deletion. Thus, Mls-1 a
Ag appeared to have been transferred from recipient cells to the Ia+ cells derived from donor …
