[HTML][HTML] Tyrosine phosphorylation of 3BP2 regulates B cell receptor-mediated activation of NFAT
U Shukla, T Hatani, K Nakashima, K Ogi… - Journal of biological …, 2009 - ASBMB
Adaptor protein c-Abl SH3 domain-binding protein-2 (3BP2, also referred to SH3BP2)
regulates immune receptor-mediated signal transduction. In this report we focused on the
molecular mechanism of 3BP2 function in B cell receptor (BCR) signaling. Engagement of
BCR induces tyrosine phosphorylation of 3BP2. Genetic analysis demonstrated that Syk is
critical for BCR-mediated tyrosine phosphorylation of 3BP2. Mutational analysis of 3BP2
revealed that both Tyr 183 and Src homology 2 (SH2) domain are necessary for 3BP2 …
regulates immune receptor-mediated signal transduction. In this report we focused on the
molecular mechanism of 3BP2 function in B cell receptor (BCR) signaling. Engagement of
BCR induces tyrosine phosphorylation of 3BP2. Genetic analysis demonstrated that Syk is
critical for BCR-mediated tyrosine phosphorylation of 3BP2. Mutational analysis of 3BP2
revealed that both Tyr 183 and Src homology 2 (SH2) domain are necessary for 3BP2 …