[HTML][HTML] Deficiency of the G-protein α-subunit Gsα in osteoblasts leads to differential effects on trabecular and cortical bone
A Sakamoto, M Chen, T Nakamura, T Xie… - Journal of Biological …, 2005 - ASBMB
The G-protein α-subunit G s α is required for the intracellular cAMP responses to hormones
and other agonists. G s α is known to mediate the cAMP response to parathyroid hormone
and other hormones and cytokines in bone and cartilage. To analyze the in vivo role of G s α
signaling in osteoblasts, we developed mice with osteoblast/osteocyte-specific G s α
deficiency (BGsKO) by mating G s α-floxed mice with collagen Iα1 promoter-Cre
recombinase transgenic mice. Early skeletal development was normal in BGsKO mice …
and other agonists. G s α is known to mediate the cAMP response to parathyroid hormone
and other hormones and cytokines in bone and cartilage. To analyze the in vivo role of G s α
signaling in osteoblasts, we developed mice with osteoblast/osteocyte-specific G s α
deficiency (BGsKO) by mating G s α-floxed mice with collagen Iα1 promoter-Cre
recombinase transgenic mice. Early skeletal development was normal in BGsKO mice …