Extracellular matrix production and degradation by bone cells are critical steps in bone
metabolism. Mutations of the gene encoding MMP-2, an extracellular matrix-degrading
enzyme, are associated with a human genetic disorder characterized by subcutaneous
nodules, arthropathy, and focal osteolysis. It is not known how the loss of MMP-2 function
results in the pathology. Here, we show that Mmp2-/-mice exhibited opposing bone
phenotypes caused by an impaired osteocytic canalicular network. Mmp2-/-mice showed …