[HTML][HTML] Odontoblast cells immortalized by telomerase produce mineralized dentin-like tissue both in vitro and in vivo
J Hao, K Narayanan, A Ramachandran, G He… - Journal of Biological …, 2002 - ASBMB
The formation of dentin provides one well accepted paradigm for studying mineralized tissue
formation. For the assembly of dentin, several cellular signaling pathways cooperate to
provide neural crest-derived mesenchymal cells with positional information. Further," cross-
talk" between signaling pathways from the mesenchymal derived odontoblast cells and the
epithelially derived ameloblasts during development is responsible for the formation of
functional odontoblasts. These intercellular signals are tightly regulated, both temporally and …
formation. For the assembly of dentin, several cellular signaling pathways cooperate to
provide neural crest-derived mesenchymal cells with positional information. Further," cross-
talk" between signaling pathways from the mesenchymal derived odontoblast cells and the
epithelially derived ameloblasts during development is responsible for the formation of
functional odontoblasts. These intercellular signals are tightly regulated, both temporally and …