[HTML][HTML] TGFβ/BMP Type I Receptors ALK1 and ALK2 Are Essential for BMP9-induced Osteogenic Signaling in Mesenchymal Stem Cells [S]
J Luo, M Tang, J Huang, BC He, JL Gao, L Chen… - Journal of Biological …, 2010 - ASBMB
Mesenchymal stem cells (MSCs) are bone marrow stromal cells that can differentiate into
multiple lineages. We previously demonstrated that BMP9 is one of the most potent BMPs to
induce osteogenic differentiation of MSCs. BMP9 is one of the least studied BMPs. Whereas
ALK1, ALK5, and/or endoglin have recently been reported as potential BMP9 type I
receptors in endothelial cells, little is known about type I receptor involvement in BMP9-
induced osteogenic differentiation in MSCs. Here, we conduct a comprehensive analysis of …
multiple lineages. We previously demonstrated that BMP9 is one of the most potent BMPs to
induce osteogenic differentiation of MSCs. BMP9 is one of the least studied BMPs. Whereas
ALK1, ALK5, and/or endoglin have recently been reported as potential BMP9 type I
receptors in endothelial cells, little is known about type I receptor involvement in BMP9-
induced osteogenic differentiation in MSCs. Here, we conduct a comprehensive analysis of …