[HTML][HTML] Co-stimulation of the bone-related Runx2 P1 promoter in mesenchymal cells by SP1 and ETS transcription factors at polymorphic purine-rich DNA sequences …
Y Zhang, MQ Hassan, RL Xie, JR Hawse… - Journal of Biological …, 2009 - ASBMB
Transcriptional control of Runx2 gene expression through two alternative promoters (P1 and
P2) is critical for the execution of its function as an osteogenic cell fate determining factor. In
all vertebrates examined to date, the bone related P1 promoter contains a purine-rich region
(-303 to-128 bp in the rat) that separates two regulatory domains. The length of this region
differs dramatically between species even within the same order. Using deletion analysis,
we show that part of this purine-rich region (-200 to-128) containing a duplicated element (Y …
P2) is critical for the execution of its function as an osteogenic cell fate determining factor. In
all vertebrates examined to date, the bone related P1 promoter contains a purine-rich region
(-303 to-128 bp in the rat) that separates two regulatory domains. The length of this region
differs dramatically between species even within the same order. Using deletion analysis,
we show that part of this purine-rich region (-200 to-128) containing a duplicated element (Y …