[HTML][HTML] P2Y6 nucleotide receptors activate NF-κB and increase survival of osteoclasts
J Korcok, LN Raimundo, X Du, SM Sims… - Journal of Biological …, 2005 - ASBMB
Nucleotides, released from cells during inflammation and by mechanical stimulation, act
through the P2 family of nucleotide receptors. Previous studies have demonstrated the
expression of P2Y1 and P2Y2 receptors in osteoclasts. The aim of this study was to
determine whether osteoclast P2Y receptors signal through NF-κB, a key transcription factor
regulating osteoclastogenesis. Immunofluorescence was used to detect the p65 subunit of
NF-κB, which upon activation translocates from the cytosol to nuclei. Low levels of NF-κB …
through the P2 family of nucleotide receptors. Previous studies have demonstrated the
expression of P2Y1 and P2Y2 receptors in osteoclasts. The aim of this study was to
determine whether osteoclast P2Y receptors signal through NF-κB, a key transcription factor
regulating osteoclastogenesis. Immunofluorescence was used to detect the p65 subunit of
NF-κB, which upon activation translocates from the cytosol to nuclei. Low levels of NF-κB …
