[HTML][HTML] Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor α-mediated control of insulin-like growth factor (IGF) I receptor …
A Sunters, VJ Armstrong, G Zaman, RM Kypta… - Journal of Biological …, 2010 - ASBMB
The capacity of bones to adjust their mass and architecture to withstand the loads of
everyday activity derives from the ability of their resident cells to respond appropriately to the
strains engendered. To elucidate the mechanisms of strain responsiveness in bone cells, we
investigated in vitro the responses of primary mouse osteoblasts and UMR-106 osteoblast-
like cells to a single period of dynamic strain. This stimulates a cascade of events, including
activation of insulin-like growth factor I receptor (IGF-IR), phosphatidylinositol 3-kinase …
everyday activity derives from the ability of their resident cells to respond appropriately to the
strains engendered. To elucidate the mechanisms of strain responsiveness in bone cells, we
investigated in vitro the responses of primary mouse osteoblasts and UMR-106 osteoblast-
like cells to a single period of dynamic strain. This stimulates a cascade of events, including
activation of insulin-like growth factor I receptor (IGF-IR), phosphatidylinositol 3-kinase …
