[HTML][HTML] ATF1 phosphorylation by the ERK MAPK pathway is required for epidermal growth factor-induced c-jun expression
P Gupta, R Prywes - Journal of Biological Chemistry, 2002 - ASBMB
Epidermal growth factor induction of c-jun expression requires ATF1 and MEF2 sites in the c-
jun promoter. We find that activation of the c-jun promoter through the ATF1 site requires
phosphorylation of ATF1 at serine 63. A serine 63 to alanine mutation of ATF1 acts to block
epidermal growth factor (EGF) induction of a transfected c-jun gene. ATF1 can be
phosphorylated by mitogen-and stress-activated protein kinase 1 (MSK1), which is activated
by EGF and ERK1/2. Kinase-dead MSK1 mutants blocked EGF induction of a transfected c …
jun promoter. We find that activation of the c-jun promoter through the ATF1 site requires
phosphorylation of ATF1 at serine 63. A serine 63 to alanine mutation of ATF1 acts to block
epidermal growth factor (EGF) induction of a transfected c-jun gene. ATF1 can be
phosphorylated by mitogen-and stress-activated protein kinase 1 (MSK1), which is activated
by EGF and ERK1/2. Kinase-dead MSK1 mutants blocked EGF induction of a transfected c …