The concept of gene-environment (GxE) interactions has dramatically evolved in the last
century and has now become a central theme in studies that assess the causes of human
disease. Despite the numerous efforts to discover genes associated in asthma and allergy
through various approaches, including the recent genome-wide association studies,
investigation of GxE interactions has been mainly limited to candidate genes, candidate
environmental exposures, or both. This review discusses the various strategies from …