BACKGROUND: There are no treatments currently available for peanut allergy. Sublingual
immunotherapy (SLIT) is a novel approach to the treatment of peanut allergy. OBJECTIVE:
We sought to investigate the safety, clinical effectiveness, and immunologic changes with
SLIT in children with peanut allergy. METHODS: In this double-blind, placebo-controlled
study subjects underwent 6 months of dose escalation and 6 months of maintenance dosing
followed by a double-blind, placebo-controlled food challenge. RESULTS: Eighteen children …