Cytogenetics of 158 patients with regional or disseminated melanoma Subset analysis of near-diploid and simple karyotypes
FH Thompson, J Emerson, S Olson, R Weinstein… - Cancer genetics and …, 1995 - Elsevier
We report on the cytogenetic analyses of 158 cases of metastatic malignant melanoma,
comprised of 63 cases with regional disease (RD) and 95 cases with distant (metastatic)
disease (DD). Clonal structural abnormalities were identified in 126 (80%) cases and were
significantly increased (< 0.01 after adjusting for multiple comparisons) on chromosomes (in
order of frequency of involvement) 1, 6, 7, 11, 9, and 3. Clustering of breakpoints occurred at
1p36, 1p22-q21, 6p11-q21, 9p, 11q23-qter, 13p (especially for cases with DD), and 19q13 …
comprised of 63 cases with regional disease (RD) and 95 cases with distant (metastatic)
disease (DD). Clonal structural abnormalities were identified in 126 (80%) cases and were
significantly increased (< 0.01 after adjusting for multiple comparisons) on chromosomes (in
order of frequency of involvement) 1, 6, 7, 11, 9, and 3. Clustering of breakpoints occurred at
1p36, 1p22-q21, 6p11-q21, 9p, 11q23-qter, 13p (especially for cases with DD), and 19q13 …