We previously reported that NF-κB is constitutively activated in most human pancreatic
cancer tissues and cell lines but not in normal pancreatic tissues and immortalized
pancreatic ductal epithelial cells. IκBαM-mediated inhibition of constitutive NF-κB activity in
human pancreatic cancer cells suppressed tumorigenesis and liver metastasis in an
orthotopic nude mouse model, suggesting that constitutive NF-κB activation plays an
important role in pancreatic tumor progression and metastasis. However, the underlying …