Relation between human LPIN1, hypoxia and endoplasmic reticulum stress genes in subcutaneous and visceral adipose tissue
M Miranda, X Escoté, V Ceperuelo-Mallafré… - International journal of …, 2010 - nature.com
M Miranda, X Escoté, V Ceperuelo-Mallafré, A Megia, E Caubet, S Näf, JM Gomez…
International journal of obesity, 2010•nature.comObjective: The aim of this study was to analyze LPIN1 gene expression in human adipose
tissue in parallel with several hypoxia, angiogenic, ER stress and peroxisome proliferator-
activated receptor (PPAR)-related genes in human obesity. Design and Patients: Gene
expression was quantified in abdominal (subcutaneous and visceral) adipose tissue from 62
subjects. Results: We have shown a marked association between LPIN1 and PPARα gene
expression both in subcutaneous and visceral adipose tissues. Similarly, a strong …
tissue in parallel with several hypoxia, angiogenic, ER stress and peroxisome proliferator-
activated receptor (PPAR)-related genes in human obesity. Design and Patients: Gene
expression was quantified in abdominal (subcutaneous and visceral) adipose tissue from 62
subjects. Results: We have shown a marked association between LPIN1 and PPARα gene
expression both in subcutaneous and visceral adipose tissues. Similarly, a strong …
Objective:
The aim of this study was to analyze LPIN1 gene expression in human adipose tissue in parallel with several hypoxia, angiogenic, ER stress and peroxisome proliferator-activated receptor (PPAR)-related genes in human obesity.
Design and Patients:
Gene expression was quantified in abdominal (subcutaneous and visceral) adipose tissue from 62 subjects.
Results:
We have shown a marked association between LPIN1 and PPARα gene expression both in subcutaneous and visceral adipose tissues. Similarly, a strong interdependence with vascular endothelial growth factor (VEGF) gene expression was also described; in fact, LPIN1 and VEGF expression levels were significantly decreased with obesity to a similar extent.
Conclusion:
These associations might suggest a possible role of LPIN1 in stress conditions that occur in chronic obesity and underlie insulin resistance.
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