In recent years, a growing body of evidence has indicated that signaling molecules
previously implicated in axon guidance are important regulators of multistep tumorigenesis
and progression. Eph receptors and ephrins belong to this special class of molecules that
play important roles in both axon guidance and cancer. Tremendous progress has been
made in the past few years in both understanding the role of Eph receptors and ephrins in
cancer and designing therapeutic strategies for cancer therapy. This review will focus on …