Vinexin, CAP/ponsin, ArgBP2: a novel adaptor protein family regulating cytoskeletal organization and signal transduction
N Kioka, K Ueda, T Amachi - Cell structure and function, 2002 - jstage.jst.go.jp
N Kioka, K Ueda, T Amachi
Cell structure and function, 2002•jstage.jst.go.jpAdaptor proteins, composed of two or more protein-protein interacting modules without
enzymatic activity, regulate various cellular functions. Vinexin, CAP/ponsin, and ArgBP2
constitute a novel adaptor protein family. They have a novel conserved region homologous
to the active peptide sorbin, as well as three SH3 (src homology 3) domains. A number of
proteins binding to this adaptor family have been identified. There is accumulating evidence
that this protein family regulates cell adhesion, cytoskeletal organization, and growth factor …
enzymatic activity, regulate various cellular functions. Vinexin, CAP/ponsin, and ArgBP2
constitute a novel adaptor protein family. They have a novel conserved region homologous
to the active peptide sorbin, as well as three SH3 (src homology 3) domains. A number of
proteins binding to this adaptor family have been identified. There is accumulating evidence
that this protein family regulates cell adhesion, cytoskeletal organization, and growth factor …
Abstract
Adaptor proteins, composed of two or more protein-protein interacting modules without enzymatic activity, regulate various cellular functions. Vinexin, CAP/ponsin, and ArgBP2 constitute a novel adaptor protein family. They have a novel conserved region homologous to the active peptide sorbin, as well as three SH3 (src homology 3) domains. A number of proteins binding to this adaptor family have been identified. There is accumulating evidence that this protein family regulates cell adhesion, cytoskeletal organization, and growth factor signaling. This review will summarize the structure and the function of proteins in this family.
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