Studies of peripheral sensory nerves in paclitaxel-induced painful peripheral neuropathy: evidence for mitochondrial dysfunction
SJL Flatters, GJ Bennett - Pain, 2006 - Elsevier
Paclitaxel chemotherapy frequently induces neuropathic pain during and often persisting
after therapy. The mechanisms responsible for this pain are unknown. Using a rat model of
paclitaxel-induced painful peripheral neuropathy, we have performed studies to search for
peripheral nerve pathology. Paclitaxel-induced mechano-allodynia and mechano-
hyperalgesia were evident after a short delay, peaked at day 27 and finally resolved on day
155. Paclitaxel-and vehicle-treated rats were perfused on days 7, 27 and 160. Portions of …
after therapy. The mechanisms responsible for this pain are unknown. Using a rat model of
paclitaxel-induced painful peripheral neuropathy, we have performed studies to search for
peripheral nerve pathology. Paclitaxel-induced mechano-allodynia and mechano-
hyperalgesia were evident after a short delay, peaked at day 27 and finally resolved on day
155. Paclitaxel-and vehicle-treated rats were perfused on days 7, 27 and 160. Portions of …
