Ovol2 suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing c-Myc and Notch1
J Wells, B Lee, AQ Cai, A Karapetyan, WJ Lee… - Journal of biological …, 2009 - ASBMB
Ovol2 belongs to the Ovo family of evolutionarily conserved zinc finger transcription factors
that act downstream of key developmental signaling pathways including Wg/Wnt and
BMP/TGF-β. We previously reported Ovol2 expression in the basal layer of epidermis, where
epidermal stem/progenitor cells reside. In this work, we use HaCaT human keratinocytes to
investigate the cellular and molecular functions of Ovol2. We show that depletion of Ovol2
leads to transient cell expansion but a loss of cells with long term proliferation potential …
that act downstream of key developmental signaling pathways including Wg/Wnt and
BMP/TGF-β. We previously reported Ovol2 expression in the basal layer of epidermis, where
epidermal stem/progenitor cells reside. In this work, we use HaCaT human keratinocytes to
investigate the cellular and molecular functions of Ovol2. We show that depletion of Ovol2
leads to transient cell expansion but a loss of cells with long term proliferation potential …
