[HTML][HTML] Activation of protein kinase Cα by EPAC1 is required for the ERK-and CCAAT/enhancer-binding protein β-dependent induction of the SOCS-3 gene by cyclic …
We recently found that induction of the anti-inflammatory SOCS-3 gene by cyclic AMP occurs
through novel cyclic AMP-dependent protein kinase-independent mechanisms involving
activation of CCAAT/enhancer-binding protein (C/EBP) transcription factors, notably
C/EBPβ, by the cyclic AMP GEF EPAC1 and the Rap1 GTPase. In this study we show that
down-regulation of phospholipase (PL) Cϵ with small interfering RNA or blockade of PLC
activity with chemical inhibitors ablates exchange protein directly activated by cyclic AMP …
through novel cyclic AMP-dependent protein kinase-independent mechanisms involving
activation of CCAAT/enhancer-binding protein (C/EBP) transcription factors, notably
C/EBPβ, by the cyclic AMP GEF EPAC1 and the Rap1 GTPase. In this study we show that
down-regulation of phospholipase (PL) Cϵ with small interfering RNA or blockade of PLC
activity with chemical inhibitors ablates exchange protein directly activated by cyclic AMP …