Heme oxygenase-1 and heat shock protein 70 induction in glia and neurons throughout rat brain after experimental intracerebral hemorrhage
PG Matz, PR Weinstein, FR Sharp - Neurosurgery, 1997 - journals.lww.com
OBJECTIVE: Current experimental evidence demonstrates the development of ischemic
regions adjacent to and spatially remote from an intracerebral hematoma. The cause of this
ischemia is uncertain. Because ischemia is a known inducer of stress genes, we
investigated the induction of two stress proteins, heme oxygenase (HO)-1 and heat shock
protein (Hsp) 70, after intracerebral hemorrhage in the rat. METHODS: Immunocytochemistry
for HO-1, Hsp70, and HO-2, the constitutive isoform of the HO enzyme, was performed 1, 2 …
regions adjacent to and spatially remote from an intracerebral hematoma. The cause of this
ischemia is uncertain. Because ischemia is a known inducer of stress genes, we
investigated the induction of two stress proteins, heme oxygenase (HO)-1 and heat shock
protein (Hsp) 70, after intracerebral hemorrhage in the rat. METHODS: Immunocytochemistry
for HO-1, Hsp70, and HO-2, the constitutive isoform of the HO enzyme, was performed 1, 2 …
