[HTML][HTML] Peptide combinatorial libraries identify TSC2 as a death-associated protein kinase (DAPK) death domain-binding protein and reveal a stimulatory role for …
C Stevens, Y Lin, B Harrison, L Burch… - Journal of Biological …, 2009 - ASBMB
Death-associated protein kinase (DAPK) is a multidomain enzyme that plays a central role in
autophagic and apoptotic signaling, although the protein-protein interactions regulating
DAPK functions are not well defined. Peptide aptamer libraries were used to identify the
tumor suppressor protein tuberin (TSC2) as a novel DAPK death domain-binding protein,
and we evaluated whether DAPK is a positive or negative effector of the TSC2-regulated
mammalian target of rapamycin (mTORC1) signaling pathway. Binding studies using death …
autophagic and apoptotic signaling, although the protein-protein interactions regulating
DAPK functions are not well defined. Peptide aptamer libraries were used to identify the
tumor suppressor protein tuberin (TSC2) as a novel DAPK death domain-binding protein,
and we evaluated whether DAPK is a positive or negative effector of the TSC2-regulated
mammalian target of rapamycin (mTORC1) signaling pathway. Binding studies using death …
