A better understanding of why murine models of trauma do not recapitulate the human syndrome
LF Gentile, DC Nacionales, MC Lopez… - Critical care …, 2014 - journals.lww.com
Objective: Genomic analyses from blood leukocytes have concluded that mouse injury
poorly reflects human trauma at the leukocyte transcriptome. Concerns have focused on the
modest severity of murine injury models, differences in murine compared with human age,
dissimilar circulating leukocyte populations between species, and whether similar signaling
pathways are involved. We sought to examine whether the transcriptomic response to
severe trauma in mice could be explained by these extrinsic factors, by utilizing an …
poorly reflects human trauma at the leukocyte transcriptome. Concerns have focused on the
modest severity of murine injury models, differences in murine compared with human age,
dissimilar circulating leukocyte populations between species, and whether similar signaling
pathways are involved. We sought to examine whether the transcriptomic response to
severe trauma in mice could be explained by these extrinsic factors, by utilizing an …
