MicroRNA-31 activates the RAS pathway and functions as an oncogenic MicroRNA in human colorectal cancer by repressing RAS p21 GTPase activating protein 1 …
D Sun, F Yu, Y Ma, R Zhao, X Chen, J Zhu… - Journal of Biological …, 2013 - ASBMB
MicroRNAs (miRNAs) are known to play a vital role in colorectal cancer. We found a
widespread disruption in miRNA expression during colorectal tumorigenesis using
microarray and quantitative RT-PCR analysis; of the 161 miRNAs altered in colorectal
cancer compared with normal adjacent tissue samples, miR-31 was the most significantly
dysregulated. We identified candidate targets of miR-31 using bioinformatics approaches
and validated RAS p21 GTPase activating protein 1 (RASA1) as a direct target. First, we …
widespread disruption in miRNA expression during colorectal tumorigenesis using
microarray and quantitative RT-PCR analysis; of the 161 miRNAs altered in colorectal
cancer compared with normal adjacent tissue samples, miR-31 was the most significantly
dysregulated. We identified candidate targets of miR-31 using bioinformatics approaches
and validated RAS p21 GTPase activating protein 1 (RASA1) as a direct target. First, we …