Vitamin D metabolism within bone cells: effects on bone structure and strength
Molecular and cellular endocrinology, 2011•Elsevier
The endocrine activity of 1, 25-dihydroxyvitamin D (1, 25 (OH) 2D3) contributes to
maintaining plasma calcium and phosphate homeostasis through actions on the intestine,
kidney and bone. A significant body of evidence has been published over the last 10years
indicating that all major bone cells have the capacity to metabolise 25-hydroxyvitamin D (25
(OH) D3) to 1, 25 (OH) 2D3, which in turn exerts autocrine/paracrine actions to regulate
bone cell proliferation and maturation as well as bone mineralisation and resorption. In vivo …
maintaining plasma calcium and phosphate homeostasis through actions on the intestine,
kidney and bone. A significant body of evidence has been published over the last 10years
indicating that all major bone cells have the capacity to metabolise 25-hydroxyvitamin D (25
(OH) D3) to 1, 25 (OH) 2D3, which in turn exerts autocrine/paracrine actions to regulate
bone cell proliferation and maturation as well as bone mineralisation and resorption. In vivo …
The endocrine activity of 1,25-dihydroxyvitamin D (1,25(OH)2D3) contributes to maintaining plasma calcium and phosphate homeostasis through actions on the intestine, kidney and bone. A significant body of evidence has been published over the last 10years indicating that all major bone cells have the capacity to metabolise 25-hydroxyvitamin D (25(OH)D3) to 1,25(OH)2D3, which in turn exerts autocrine/paracrine actions to regulate bone cell proliferation and maturation as well as bone mineralisation and resorption. In vivo and in vitro studies indicate that these autocrine/paracrine activities of 1,25(OH)2D3 in bone tissue contribute to maintaining bone mineral homeostasis and enhancing skeletal health.
Elsevier