[HTML][HTML] A Feedback Loop between the Androgen Receptor and a NEDD4-binding Protein, PMEPA1, in Prostate Cancer Cells∗
H Li, LL Xu, K Masuda, E Raymundo… - Journal of biological …, 2008 - ASBMB
PMEPA1 was identified originally as a highly androgen-inducible gene with prostate-
abundant expression that was restricted to prostatic epithelial cells. PMEPA1 protein is a
NEDD4 (ubiquitin-protein isopeptide ligase)-binding protein, which negatively regulates
prostate cancer cell growth. In this study we establish that PMEPA1 is a direct transcriptional
target of the androgen receptor (AR). We also demonstrate that PMEPA1 negatively
regulates AR protein levels in different cell culture models. Transient expression of PMEPA1 …
abundant expression that was restricted to prostatic epithelial cells. PMEPA1 protein is a
NEDD4 (ubiquitin-protein isopeptide ligase)-binding protein, which negatively regulates
prostate cancer cell growth. In this study we establish that PMEPA1 is a direct transcriptional
target of the androgen receptor (AR). We also demonstrate that PMEPA1 negatively
regulates AR protein levels in different cell culture models. Transient expression of PMEPA1 …