[HTML][HTML] Neutralization of macrophage migration inhibitory factor (MIF) by fully human antibodies correlates with their specificity for the β-sheet structure of MIF
RJ Kerschbaumer, M Rieger, D Völkel, D Le Roy… - Journal of Biological …, 2012 - ASBMB
The macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that recently
emerged as an attractive therapeutic target for a variety of diseases. A diverse panel of fully
human anti-MIF antibodies was generated by selection from a phage display library and
extensively analyzed in vitro. Epitope mapping studies identified antibodies specific for
linear as well as structural epitopes. Experimental animal studies revealed that only those
antibodies binding epitopes within amino acids 50–68 or 86–102 of the MIF molecule …
emerged as an attractive therapeutic target for a variety of diseases. A diverse panel of fully
human anti-MIF antibodies was generated by selection from a phage display library and
extensively analyzed in vitro. Epitope mapping studies identified antibodies specific for
linear as well as structural epitopes. Experimental animal studies revealed that only those
antibodies binding epitopes within amino acids 50–68 or 86–102 of the MIF molecule …