Recent studies have indicated an important role of chemokines such as CCL2 in the
development of chronic pain. However, the distinct roles of different chemokines in the
development and maintenance of neuropathic pain and in their interactions with neurons
have not been clearly elucidated. We found that spinal nerve ligation (SNL) not only induced
persistent neuropathic pain symptoms, including mechanical allodynia and heat
hyperalgesia, but also produced sustained CXCL1 upregulation in the spinal cord. Double …