Aberrant epigenetic regulation of bromodomain BRD4 in human colon cancer
RM Rodriguez, C Huidobro, RG Urdinguio… - Journal of molecular …, 2012 - Springer
RM Rodriguez, C Huidobro, RG Urdinguio, C Mangas, B Soldevilla, G Dominguez, F Bonilla…
Journal of molecular medicine, 2012•SpringerThe bromodomain protein BRD4 is involved in cell proliferation and cell cycle progression,
primarily through its role in acetylated chromatin-dependent regulation of transcription at
targeted loci. Here, we show that BRD4 is frequently downregulated by aberrant promoter
hypermethylation in human colon cancer cell lines and primary tumors. Ectopic re-
expression of BRD4 in these colon cancer cell lines markedly reduced in vivo tumor growth,
suggesting a role of BRD4 in human colon cancer.
primarily through its role in acetylated chromatin-dependent regulation of transcription at
targeted loci. Here, we show that BRD4 is frequently downregulated by aberrant promoter
hypermethylation in human colon cancer cell lines and primary tumors. Ectopic re-
expression of BRD4 in these colon cancer cell lines markedly reduced in vivo tumor growth,
suggesting a role of BRD4 in human colon cancer.
Abstract
The bromodomain protein BRD4 is involved in cell proliferation and cell cycle progression, primarily through its role in acetylated chromatin-dependent regulation of transcription at targeted loci. Here, we show that BRD4 is frequently downregulated by aberrant promoter hypermethylation in human colon cancer cell lines and primary tumors. Ectopic re-expression of BRD4 in these colon cancer cell lines markedly reduced in vivo tumor growth, suggesting a role of BRD4 in human colon cancer.
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