[HTML][HTML] Intertissue flow of glutathione (GSH) as a tumor growth-promoting mechanism: interleukin 6 induces GSH release from hepatocytes in metastatic B16 …
E Obrador, M Benlloch, JA Pellicer, M Asensi… - Journal of Biological …, 2011 - ASBMB
B16 melanoma F10 (B16-F10) cells with high glutathione (GSH) content show high
metastatic activity in vivo. An intertissue flow of GSH, where the liver is the main reservoir,
can increase GSH content in metastatic cells and promote their growth. We have studied
here possible tumor-derived molecular signals that could activate GSH release from
hepatocytes. GSH efflux increases in hepatocytes isolated from mice bearing liver or lung
metastases, thus suggesting a systemic mechanism. Fractionation of serum-free conditioned …
metastatic activity in vivo. An intertissue flow of GSH, where the liver is the main reservoir,
can increase GSH content in metastatic cells and promote their growth. We have studied
here possible tumor-derived molecular signals that could activate GSH release from
hepatocytes. GSH efflux increases in hepatocytes isolated from mice bearing liver or lung
metastases, thus suggesting a systemic mechanism. Fractionation of serum-free conditioned …