[HTML][HTML] Strain-and host species-specific inflammasome activation, IL-1β release, and cell death in macrophages infected with uropathogenic Escherichia coli
Uropathogenic Escherichia coli (UPEC) is the main etiological agent of urinary tract
infections (UTIs). Little is known about interactions between UPEC and the inflammasome, a
key innate immune pathway. Here we show that UPEC strains CFT073 and UTI89 trigger
inflammasome activation and lytic cell death in human macrophages. Several other UPEC
strains, including two multidrug-resistant ST131 isolates, did not kill macrophages. In mouse
macrophages, UTI89 triggered cell death only at a high multiplicity of infection, and CFT073 …
infections (UTIs). Little is known about interactions between UPEC and the inflammasome, a
key innate immune pathway. Here we show that UPEC strains CFT073 and UTI89 trigger
inflammasome activation and lytic cell death in human macrophages. Several other UPEC
strains, including two multidrug-resistant ST131 isolates, did not kill macrophages. In mouse
macrophages, UTI89 triggered cell death only at a high multiplicity of infection, and CFT073 …