p57KIP2: “Kip”ing the Cell under Control
IS Pateras, K Apostolopoulou, K Niforou… - Molecular Cancer …, 2009 - AACR
Molecular Cancer Research, 2009•AACR
Abstract p57KIP2 is an imprinted gene located at the chromosomal locus 11p15. 5. It is a
cyclin-dependent kinase inhibitor belonging to the CIP/KIP family, which includes
additionally p21CIP1/WAF1 and p27KIP1. It is the least studied CIP/KIP member and has a
unique role in embryogenesis. p57KIP2 regulates the cell cycle, although novel functions
have been attributed to this protein including cytoskeletal organization. Molecular analysis of
animal models and patients with Beckwith-Wiedemann Syndrome have shown its nodal …
cyclin-dependent kinase inhibitor belonging to the CIP/KIP family, which includes
additionally p21CIP1/WAF1 and p27KIP1. It is the least studied CIP/KIP member and has a
unique role in embryogenesis. p57KIP2 regulates the cell cycle, although novel functions
have been attributed to this protein including cytoskeletal organization. Molecular analysis of
animal models and patients with Beckwith-Wiedemann Syndrome have shown its nodal …
Abstract
p57KIP2 is an imprinted gene located at the chromosomal locus 11p15.5. It is a cyclin-dependent kinase inhibitor belonging to the CIP/KIP family, which includes additionally p21CIP1/WAF1 and p27KIP1. It is the least studied CIP/KIP member and has a unique role in embryogenesis. p57KIP2 regulates the cell cycle, although novel functions have been attributed to this protein including cytoskeletal organization. Molecular analysis of animal models and patients with Beckwith-Wiedemann Syndrome have shown its nodal implication in the pathogenesis of this syndrome. p57KIP2 is frequently down-regulated in many common human malignancies through several mechanisms, denoting its anti-oncogenic function. This review is a thorough analysis of data available on p57KIP2, in relation to p21CIP1/WAF1 and p27KIP1, on gene and protein structure, its transcriptional and translational regulation, and its role in human physiology and pathology, focusing on cancer development. (Mol Cancer Res 2009;7(12):1902–19)
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