Mild-to-moderate hypertriglyceridemia in young men is associated with endothelial dysfunction and increased plasma concentrations of asymmetric dimethylarginine
P Lundman, MJ Eriksson, M Stühlinger… - Journal of the American …, 2001 - jacc.org
P Lundman, MJ Eriksson, M Stühlinger, JP Cooke, A Hamsten, P Tornvall
Journal of the American College of Cardiology, 2001•jacc.orgOBJECTIVES The aim of this study was to investigate endothelial function and common
carotid intima-media thickness (IMT) in healthy young men with mild-to-moderate
hypertriglyceridemia. Plasma asymmetric dimethylarginine (ADMA), an endogenous nitric
oxide synthase inhibitor, was measured to further elucidate the mechanisms involved.
BACKGROUND Hypertriglyceridemia is a risk factor for coronary heart disease although the
mechanisms behind the increased risk remain to be defined. Acute elevation of plasma …
carotid intima-media thickness (IMT) in healthy young men with mild-to-moderate
hypertriglyceridemia. Plasma asymmetric dimethylarginine (ADMA), an endogenous nitric
oxide synthase inhibitor, was measured to further elucidate the mechanisms involved.
BACKGROUND Hypertriglyceridemia is a risk factor for coronary heart disease although the
mechanisms behind the increased risk remain to be defined. Acute elevation of plasma …
Abstract
OBJECTIVES
The aim of this study was to investigate endothelial function and common carotid intima-media thickness (IMT) in healthy young men with mild-to-moderate hypertriglyceridemia. Plasma asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, was measured to further elucidate the mechanisms involved.
BACKGROUND
Hypertriglyceridemia is a risk factor for coronary heart disease although the mechanisms behind the increased risk remain to be defined. Acute elevation of plasma triglycerides induced by an intravenous fat load is associated with impaired endothelial function. The results of studies examining acute effects induced by a high-fat meal or effects of chronic hypertriglyceridemia on endothelial function are more inconsistent.
METHODS
Flow-mediated vasodilation and nitroglycerin-induced vasodilation of the brachial artery and common carotid IMT were measured noninvasively by ultrasound technique in 15 hypertriglyceridemic (HTG) subjects and 15 matched controls, mean age 34 years. Plasma concentrations of ADMA were measured by high-performance liquid chromatography.
RESULTS
Flow-mediated vasodilation was decreased in the HTG group (p < 0.0001), whereas nitroglycerin-induced vasodilation and carotid IMT did not differ significantly. Asymmetric dimethylarginine concentrations were higher in the HTG group (p < 0.05).
CONCLUSIONS
Hypertriglyceridemia in young men is associated with endothelial dysfunction and increased plasma concentration of ADMA but not with increased IMT of the common carotid artery. The corollary is that chronic hypertriglyceridemia results in endothelial dysfunction, possibly due to increased ADMA concentration, and that endothelial dysfunction might precede increased IMT among the early manifestations of atherosclerosis.
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