The history of hepatitis C virus (HCV): Basic research reveals unique features in phylogeny, evolution and the viral life cycle with new perspectives for epidemic control
J Bukh - Journal of hepatology, 2016 - Elsevier
The discovery of hepatitis C virus (HCV) in 1989 permitted basic research to unravel critical
components of a complex life cycle for this important human pathogen. HCV is a highly
divergent group of viruses classified in 7 major genotypes and a great number of subtypes,
and circulating in infected individuals as a continuously evolving quasispecies destined to
escape host immune responses and applied antivirals. Despite the inability to culture patient
viruses directly in the laboratory, efforts to define the infectious genome of HCV resulted in …
components of a complex life cycle for this important human pathogen. HCV is a highly
divergent group of viruses classified in 7 major genotypes and a great number of subtypes,
and circulating in infected individuals as a continuously evolving quasispecies destined to
escape host immune responses and applied antivirals. Despite the inability to culture patient
viruses directly in the laboratory, efforts to define the infectious genome of HCV resulted in …
