Human duodenal epithelial cells constitutively express molecular components of antigen presentation but not costimulatory molecules
B Byrne, L Madrigal-Estebas, A McEvoy, J Carton… - Human Immunology, 2002 - Elsevier
Constitutive expression of major histocompatibility complex (MHC) class II molecules by
duodenal epithelial cells (EC) suggests that they can present antigen to CD4+ T cells.
However, other molecular components including invariant chain (Ii), HLA-DM, and
costimulatory molecules CD80, CD86 and CD40, are required for efficient T-cell activation.
We have investigated whether normal human duodenal EC possess these molecules and
whether they can mediate MHC class II antigen presentation. EC were isolated from …
duodenal epithelial cells (EC) suggests that they can present antigen to CD4+ T cells.
However, other molecular components including invariant chain (Ii), HLA-DM, and
costimulatory molecules CD80, CD86 and CD40, are required for efficient T-cell activation.
We have investigated whether normal human duodenal EC possess these molecules and
whether they can mediate MHC class II antigen presentation. EC were isolated from …
