Viscero-somatic referral and sensitization has been well documented clinically and widely
investigated, whereas viscero-visceral referral and sensitization (termed cross-organ
sensitization) has only recently received attention as important to visceral disease states.
Because second order neurons in the CNS have been extensively shown to receive
convergent input from different visceral organs, it has been assumed that cross-organ
sensitization arises by the same convergence-projection mechanism as advanced for …