Crohn's disease and cystic fibrosis
JD Lloyd-Still - Digestive diseases and sciences, 1994 - Springer
JD Lloyd-Still
Digestive diseases and sciences, 1994•SpringerAdvances in investigative techniques have led to increasing reports of Crohn's disease in
CF patients. A retrospective review of the literature on IBD in CF showed findings
characterized by ileocolitis with fistula formation; 83% required surgery. A prospective
survey of 11,321 CF patients attending 49 CF centers revealed 28 with IBD (25 Crohn's,
three ulcerative colitis), ages 4–20 years, mean 15.6 years. The prevalence rate of IBD
(247/10 5) was 7× controls and was accounted for by Crohn's disease (221/10 5) which was …
CF patients. A retrospective review of the literature on IBD in CF showed findings
characterized by ileocolitis with fistula formation; 83% required surgery. A prospective
survey of 11,321 CF patients attending 49 CF centers revealed 28 with IBD (25 Crohn's,
three ulcerative colitis), ages 4–20 years, mean 15.6 years. The prevalence rate of IBD
(247/10 5) was 7× controls and was accounted for by Crohn's disease (221/10 5) which was …
Abstract
Advances in investigative techniques have led to increasing reports of Crohn's disease in CF patients. A retrospective review of the literature on IBD in CF showed findings characterized by ileocolitis with fistula formation; 83% required surgery. A prospective survey of 11,321 CF patients attending 49 CF centers revealed 28 with IBD (25 Crohn's, three ulcerative colitis), ages 4–20 years, mean 15.6 years. The prevalence rate of IBD (247/105) was 7× controls and was accounted for by Crohn's disease (221/105) which was 17× controls. The mechanisms that predispose CF patients to Crohn's disease are discussed.
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