[HTML][HTML] Ndr protein kinase is regulated by phosphorylation on two conserved sequence motifs
TA Millward, D Hess, BA Hemmings - Journal of Biological Chemistry, 1999 - ASBMB
Ndr is a nuclear serine/threonine protein kinase that belongs to a subfamily of kinases
implicated in the regulation of cell division and cell morphology. This subfamily includes the
kinases LATS, Orb6, Cot-1, and Dbf2. We show here that Ndr is potently activated when
intact cells are treated with okadaic acid, suggesting that Ndr is normally held in a state of
low activity by protein phosphatase 2A. We mapped the regulatory phosphorylation sites of
Ndr protein kinase and found that active Ndr is phosphorylated on Ser-281 and Thr-444 …
implicated in the regulation of cell division and cell morphology. This subfamily includes the
kinases LATS, Orb6, Cot-1, and Dbf2. We show here that Ndr is potently activated when
intact cells are treated with okadaic acid, suggesting that Ndr is normally held in a state of
low activity by protein phosphatase 2A. We mapped the regulatory phosphorylation sites of
Ndr protein kinase and found that active Ndr is phosphorylated on Ser-281 and Thr-444 …
