Activating the nucleic acid-sensing machinery for anticancer immunity
T Medler, JM Patel, A Alice, JR Baird, HM Hu… - International review of …, 2019 - Elsevier
Nucleic acid sensing pathways have likely evolved as part of a broad pathogen sensing
strategy intended to discriminate infectious agents and initiate appropriate innate and
adaptive controls. However, in the absence of infectious agents, nucleic acid sensing
pathways have been shown to play positive and negative roles in regulating tumorigenesis,
tumor progression and metastatic spread. Understanding the normal biology behind these
pathways and how they are regulated in malignant cells and in the tumor immune …
strategy intended to discriminate infectious agents and initiate appropriate innate and
adaptive controls. However, in the absence of infectious agents, nucleic acid sensing
pathways have been shown to play positive and negative roles in regulating tumorigenesis,
tumor progression and metastatic spread. Understanding the normal biology behind these
pathways and how they are regulated in malignant cells and in the tumor immune …