The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA
S Lutz, A Freichel-Blomquist, Y Yang… - Journal of Biological …, 2005 - ASBMB
The monomeric GTPase RhoA, which is a key regulator of numerous cellular processes, is
activated by a variety of G protein-coupled receptors, through either G 12 or G q family
proteins. Here we report that p63RhoGEF, a recently identified RhoA-specific guanine
nucleotide exchange factor, enhances the Rho-dependent gene transcription induced by
agonist-stimulated G q/11-coupled receptors (M 3-cholinoceptor, histamine H 1 receptor) or
GTPase-deficient mutants of Gα q and Gα 11. We further demonstrate that active Gα q or Gα …
activated by a variety of G protein-coupled receptors, through either G 12 or G q family
proteins. Here we report that p63RhoGEF, a recently identified RhoA-specific guanine
nucleotide exchange factor, enhances the Rho-dependent gene transcription induced by
agonist-stimulated G q/11-coupled receptors (M 3-cholinoceptor, histamine H 1 receptor) or
GTPase-deficient mutants of Gα q and Gα 11. We further demonstrate that active Gα q or Gα …
