[HTML][HTML] Selective regulation of Gαq/11 by an RGS domain in the G protein-coupled receptor kinase, GRK2
G protein-coupled receptor kinases (GRKs) are well characterized regulators of G protein-
coupled receptors, whereas regulators of G protein signaling (RGS) proteins directly control
the activity of G protein α subunits. Interestingly, a recent report (Siderovski, DP, Hessel, A.,
Chung, S., Mak, TW, and Tyers, M.(1996) Curr. Biol. 6, 211–212) identified a region within
the N terminus of GRKs that contained homology to RGS domains. Given that RGS domains
demonstrate AlF 4−-dependent binding to G protein α subunits, we tested the ability of G …
coupled receptors, whereas regulators of G protein signaling (RGS) proteins directly control
the activity of G protein α subunits. Interestingly, a recent report (Siderovski, DP, Hessel, A.,
Chung, S., Mak, TW, and Tyers, M.(1996) Curr. Biol. 6, 211–212) identified a region within
the N terminus of GRKs that contained homology to RGS domains. Given that RGS domains
demonstrate AlF 4−-dependent binding to G protein α subunits, we tested the ability of G …
