[HTML][HTML] Heterotrimeric Gαq/Gα11 proteins function upstream of vascular endothelial growth factor (VEGF) receptor-2 (KDR) phosphorylation in vascular permeability …
H Zeng, D Zhao, S Yang, K Datta… - Journal of Biological …, 2003 - ASBMB
Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) functions by
activating two receptor-tyrosine kinases, Flt-1 (VEGF receptor (VEGFR)-1) and KDR (VEGFR-
2), both of which are selectively expressed on primary vascular endothelium. KDR is
responsible for VPF/VEGF-stimulated endothelial cell proliferation and migration, whereas
Flt-1 down-modulates KDR-mediated endothelial cell proliferation. Our most recent works
show that pertussis toxin-sensitive G proteins and Gβγ subunits are required for Flt-1 …
activating two receptor-tyrosine kinases, Flt-1 (VEGF receptor (VEGFR)-1) and KDR (VEGFR-
2), both of which are selectively expressed on primary vascular endothelium. KDR is
responsible for VPF/VEGF-stimulated endothelial cell proliferation and migration, whereas
Flt-1 down-modulates KDR-mediated endothelial cell proliferation. Our most recent works
show that pertussis toxin-sensitive G proteins and Gβγ subunits are required for Flt-1 …
